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In stable environments, cell size fluctuations are thought to be governed bysimple physical principles, as suggested by recent findings of scalingproperties. Here, by developing a microfluidic device and using E. coli, weinvestigate the response of cell size fluctuations against starvation. Byabruptly switching to non-nutritious medium, we find that the cell sizedistribution changes but satisfies scale invariance: the rescaled distributionis kept unchanged and determined by the growth condition before starvation.These findings are underpinned by a model based on cell growth and cell cycle.Further, we numerically determine the range of validity of the scale invarianceover various characteristic times of the starvation process, and find theviolation of the scale invariance for slow starvation. Our results, combinedwith theoretical arguments, suggest the relevance of the multifork replication,which helps retaining information of cell cycle states and may thus result inthe scale invariance.

Scale invariance of cell size fluctuations in starving bacteria