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Phytophthora sojae  is a pathogen that causes stem and root rot in soybean ( Glycine max  [L.] Merr.). We previously demonstrated that GmBTB/POZ, a BTB/POZ domain-containing nuclear protein, enhances resistance to  P. sojae  in soybean, via a process that depends on salicylic acid (SA). Here, we demonstrate that GmBTB/POZ associates directly with soybean LIKE HETEROCHROMATIN PROTEIN1 (GmLHP1) in vitro and in vivo and promotes its ubiquitination and degradation. Both overexpression and RNA interference analysis of transgenic lines demonstrate that GmLHP1 negatively regulates the response of soybean to  P. sojae  by reducing SA levels and repressing  GmPR1  expression. The WRKY transcription factor gene,  GmWRKY40 , a SA-induced gene in the SA signaling pathway, is targeted by GmLHP1, which represses its expression via at least two mechanisms (directly binding to its promoter and impairing SA accumulation). Furthermore, the nuclear localization of GmLHP1 is required for the GmLHP1-mediated negative regulation of immunity, SA levels and the suppression of  GmWRKY40  expression. Finally, GmBTB/POZ releases GmLHP1-regulated  GmWRKY40  suppression and increases resistance to  P. sojae  in  GmLHP1-OE  hairy roots. These findings uncover a regulatory mechanism by which GmBTB/POZ-GmLHP1 modulates resistance to  P. sojae  in soybean, likely by regulating the expression of downstream target gene  GmWRKY40 .

GmBTB/POZ promotes the ubiquitination and degradation of LHP1 to regulate the response of soybean to Phytophthora sojae