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Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates ( Symbiodinium ) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model  Exaptasia pallida  (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with  NFAT ,  ATF4 ,  GATA3 ,  SOX14 , and  PAX3  motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with  NKx3-1 ,  HNF4A ,  IRF4  motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.

The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia