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Hyperglycemia caused by excessive intake of sucrose leads to lifestyle-related diseases such as diabetes. Administration of a lactic acid bacterial strain to mice suppresses sucrose-induced hyperglycemia, but evidence for a similar effect in humans is lacking. Here we show that  Enterococcus faecalis  YM0831, identified using an in vivo screening system with silkworms, suppressed sucrose-induced hyperglycemia in humans.  E. faecalis  YM0831 also suppressed glucose-induced hyperglycemia in silkworms.  E. faecalis  YM0831 inhibited glucose uptake by the human intestinal epithelial cell line Caco-2. A transposon insertion mutant of  E. faecalis  YM0831, which showed decreased inhibitory activity against glucose uptake by Caco-2 cells, also exhibited decreased inhibitory activity against both sucrose-induced and glucose-induced hyperglycemia in silkworms. In human clinical trials, oral ingestion of  E. faecalis  YM0831 suppressed the increase in blood glucose in a sucrose tolerance test. These findings suggest that  E. faecalis  YM0831 inhibits intestinal glucose transport and suppresses sucrose-induced hyperglycemia in humans.

Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans