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Certain strains of  Escherichia coli  possess and express the toxin colibactin (Clb) which induces host mutations identical to the signature mutations of colorectal cancer (CRC) that lead to tumorigenic lesions. Since cattle are a known reservoir of several  Enterobacteriaceae  including  E. coli , this study screened for  clb  amongst  E. coli  isolated from colons of cattle-at-harvest (entering beef processing facility; n = 1430), across the beef processing continuum (feedlot to finished subprimal beef; n = 232), and in ground beef (n = 1074). Results demonstrated that  clb  +  E. coli  were present in cattle and beef. Prevalence of  clb  +  E. coli  from colonic contents of cattle and ground beef was 18.3% and 5.5%, respectively.  clb  +  E. coli  were found susceptible to commonly used meat processing interventions. Whole genome sequencing of 54 bovine and beef  clb  +  isolates showed  clb  occurred in diverse genetic backgrounds, most frequently in phylogroup B1 (70.4%), MLST 1079 (42.6%), and serogroup O49 (40.7%).

Characterization of Escherichia coli harboring colibactin genes (clb) isolated from beef production and processing systems