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To investigate the long-term effect of unilateral idiopathic epiretinal membrane (uiERM) removal on monocular and binocular visual function, and on vision-related quality of life (VR-QoL). Prospective, single-center study. The following data were collected before and after surgery: distance monocular and binocular best-corrected visual acuity (BCVA), horizontal and vertical metamorphopsia, horizontal and vertical aniseikonia, stereoacuity and National Eye Institute Visual Function Questionnaire-25 item (NEI VFQ-25). Forty-two patients (mean age: 72.7 ± 7.4 years; 24 men) were included. At 6 months postoperatively, distance monocular BCVA ( p  &lt; 0.001), horizontal metamorphopsia ( p  = 0.001) and the composite score of NEI VFQ-25 ( p  &lt; 0.001) significantly improved, in comparison to baseline. At 2 years postoperatively, distance monocular ( p  &lt; 0.001) and binocular ( p  = 0.01) BCVA, horizontal ( p  &lt; 0.001) and vertical ( p  = 0.02) metamorphopsia, vertical aniseikonia ( p  = 0.01), stereoacuity ( p  &lt; 0.001) and 3 subscales scores of the NEI VFQ-25 ( p  &lt; 0.05) (“general vision”, “mental health”, “driving”) significantly improved in comparison to baseline. Removal of uiERM improves VR-QoL and achieves good visual outcomes on both monocular and binocular visual parameters over long-term. Visual symptoms induced by macular contraction have different improvement kinetics after surgery. Stereopsis, the highest level of binocular vision, can be improved in some cases.

Long-term functional outcomes and vision-related quality of life after vitrectomy for epiretinal membrane: a prospective cohort study