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Acinetobacter  has been frequently detected in backwater areas of the Three Gorges Reservoir (TGR) region. We here employed  Caenorhabditis elegans  to perform biosafety assessment of  Acinetobacter  strains isolated from backwater area in the TGR region. Among 21 isolates and 5 reference strains of  Acinetobacter , exposure to  Acinetobacter  strains of AC1, AC15, AC18, AC21,  A. baumannii  ATCC 19606 T ,  A. junii  NH88-14, and  A. lwoffii  DSM 2403 T  resulted in significant decrease in locomotion behavior and reduction in lifespan of  Caenorhabditis elegans . In nematodes, exposure to  Acinetobacter  strains of AC1, AC15, AC18, AC21,  A. baumannii ,  A. junii  and  A. lwoffii  also resulted in significant reactive oxygen species (ROS) production. Moreover, exposure to  Acinetobacter  isolates of AC1, AC15, AC18, and AC21 led to significant increase in expressions of both SOD-3::GFP and some antimicrobial genes ( lys-1 ,  spp-12 ,  lys-7 ,  dod-6 ,  spp-1 ,  dod-22 ,  lys-8 , and/or  F55G11.4 ) in nematodes. The  Acinetobacter  isolates of AC1, AC15, AC18, and AC21 had different morphological, biochemical, phylogenetical, and virulence gene properties. Our results suggested that exposure risk of some  Acinetobacter  strains isolated from the TGR region exists for environmental organisms and human health. In addition,  C. elegans  is useful to assess biosafety of  Acinetobacter  isolates from the environment.

Biosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans