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One group of promising pest control agents are the entomopathogenic fungi; one such example is  Conidiobolus coronatus , which produces a range of metabolites. Our present findings reveal for the first time that  C. coronatus  also produces dodecanol, a compound widely used to make surfactants and pharmaceuticals, and enhance flavors in food. The main aim of the study was to determine the influence of dodecanol on insect defense systems, i.e. cuticular lipid composition and the condition of insect immunocompetent cells; hence, its effect was examined in detail on two species differing in susceptibility to fungal infection:  Galleria mellonella  and  Calliphora vicina . Dodecanol treatment elicited significant quantitative and qualitative differences in cuticular free fatty acid (FFA) profiles between the species, based on gas chromatography analysis with mass spectrometry (GC/MS), and had a negative effect on  G. mellonella  and  C. vicina  hemocytes and a Sf9 cell line in vitro: after 48 h, almost all the cells were completely disintegrated. The metabolite had a negative effect on the insect defense system, suggesting that it could play an important role during  C. coronatus  infection. Its high insecticidal activity and lack of toxicity towards vertebrates suggest it could be an effective insecticide.

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Dodecanol, metabolite of entomopathogenic fungus Conidiobolus coronatus, affects fatty acid composition and cellular immunity of Galleria mellonella and Calliphora vicina