English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Anopheles funestus  is playing an increasing role in malaria transmission in parts of sub-Saharan Africa, where  An. gambiae  s.s. has been effectively controlled by long-lasting insecticidal nets. We investigated vector population bionomics, insecticide resistance and malaria transmission dynamics in 86 study clusters in North-West Tanzania.  An. funestus  s.l. represented 94.5% (4740/5016) of all vectors and was responsible for the majority of malaria transmission (96.5%), with a sporozoite rate of 3.4% and average monthly entomological inoculation rate (EIR) of 4.57 per house. Micro-geographical heterogeneity in species composition, abundance and transmission was observed across the study district in relation to key ecological differences between northern and southern clusters, with significantly higher densities, proportions and EIR of  An. funestus  s.l. collected from the South.  An. gambiae  s.l. (5.5%) density, principally  An. arabiensis  (81.1%) and  An. gambiae  s.s. (18.9%), was much lower and closely correlated with seasonal rainfall. Both  An. funestus  s.l. and  An. gambiae  s.l. were similarly resistant to alpha-cypermethrin and permethrin. Overexpression of  CYP9K1, CYP6P3, CYP6P4  and  CYP6M2  and high L1014S- kdr  mutation frequency were detected in  An. gambiae  s.s. populations. Study findings highlight the urgent need for novel vector control tools to tackle persistent malaria transmission in the Lake Region of Tanzania.

An increasing role of pyrethroid-resistant Anopheles funestus in malaria transmission in the Lake Zone, Tanzania