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Little is known about whether early-phase PET images of  18 F-FP-CIT match those of amyloid PET. Here, we compared early-phase  18 F-FP-CIT and  18 F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase  18 F-FP-CIT PET (median, 0.86) was significantly lower than that of  18 F-flutemetamol PET (median, 0.91,  p  < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures ( p  = 0.232). The SUVR of total brain regions obtained from early  18 F-FP-CIT PET showed a very strong correlation with that of  18 F-flutemetamol PET ( rho  = 0.80,  p  < 0.001). Among the kinetic parameters, only  R 1 showed a statistically significant correlation between the two techniques for all brain regions ( rho  = 0.89,  p  < 0.001).  R 1 from  18 F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to  R 1 from  18 F-flutemetamol PET (median, 0.81,  p  < 0.001). 18 F-FP-CIT demonstrated lower uptake in cortical brain regions than  18 F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.

Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated