English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of  Streptococcus mutans  and  Candida albicans  with the onset of ECC is well known. Also,  S. mutans  strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-rich dentin and are linked to increased caries risk. Here, we investigated the presence of Cbp +   S. mutans  and  C. albicans  in saliva and dental plaque of children with varying caries statuses, and their salivary microbiome. In this cross-sectional study, 143 children who were caries-free (n = 73), treated for ECC with no signs of recurrence after 6 months (n = 45), or treated for ECC and experiencing recurrence within 6 months following treatment (n = 25) were enrolled. Co-infection with  C. albicans  and  S. mutans , especially Cbp +   S. mutans,  was strongly associated with caries recurrence. Subjects of the recurrence group infected with Cbp +   S. mutans  showed a greater burden of  Candida  spp. and of Mutans streptococci in dentin than those infected with Cbp -  strains. Salivary microbiome analysis revealed that  Streptococcus parasanguinis  was overrepresented in the caries recurrence group. Our findings indicate that Cbp +   S. mutans  and  C. albicans  are intimately associated with caries recurrence, contributing to the establishment of recalcitrant biofilms.

Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence