English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Stenotrophomonas maltophilia  exhibits wide spectrum of fluoroquinolone resistance using different mechanisms as multidrug efflux pumps and Sm qnr  alleles. Here, the role of  smeDEF ,  smeVWX  efflux genes and contribution of Sm qnr  alleles in the development of fluoroquinolone resistance was assessed. Ciprofloxacin, levofloxacin and moxifloxacin resistance were found in 10.9%, 3.5%, and 1.6% of isolates, respectively. More than four-fold differences in ciprofloxacin MICs were detected in the presence of reserpine and  smeD, F, V  expression was significantly associated with ciprofloxacin resistance (p = 0.017 for  smeD , 0.003 for  smeF , and 0.001 for  smeV ). Sm qnr  gene was found in 52% of the ciprofloxacin-resistant isolates and Sm qnr8  was the most common allele detected. Fluoroquinolone resistance in  S. maltophilia  clinical isolates was significantly associated with active efflux pumps. There was no correlation between the Sm qnr  alleles and ciprofloxacin resistance; however, contribution of the Sm qnr  genes in low-level levofloxacin resistance was revealed.

Emergence of fluoroquinolone resistance and possible mechanisms in clinical isolates of Stenotrophomonas maltophilia from Iran