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Long non-coding RNAs (lncRNAs) have important biological functions, but their involvement in ovarian cancer remains elusive. We analyzed high-throughput data to identify lncRNAs associated with ovarian cancer outcomes. Our search led to the discovery of lncRNA  TOPORS Antisense RNA 1  ( TOPORS-AS1 ). Patients with high  TOPORS-AS1  expression had favorable overall survival compared to low expression. This association was replicated in our study and confirmed by meta-analysis. In vitro experiments demonstrated that overexpressing  TOPORS-AS1  in ovarian cancer cells suppressed cell proliferation and inhibited aggressive cell behaviors, including migration, invasion, and colony formation. Analysis of tumor cell transcriptomes indicated  TOPORS-AS1 ′s influence on the Wnt/β-catenin signaling. Additional experiments revealed that  TOPORS-AS1  increased the phosphorylation of β-catenin and suppressed the expression of  CTNNB1 , disrupting the Wnt/β-catenin pathway. Our experiments further discovered that vitamin D receptor (VDR) upregulated  TOPORS-AS1  expression and that inhibition of β-catenin by  TOPORS-AS1  required a RNA binding protein, hnRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2B1). Taken together, these findings suggest that  TOPORS-AS1  may behave like a tumor suppressor in ovarian cancer through interrupting the Wnt/β-catenin signaling and that VDR upregulates the expression of  TOPORS-AS1 . Assessing  TOPORS-AS1  expression in ovarian cancer may help predict disease prognosis and develop treatment strategy

Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer