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Long non-coding RNAs (lncRNAs) are important in regulating the response to environmental stresses in organisms. In this study, we used  Caenorhabditis elegans  as an animal model to determine the functions of intestinal lncRNAs in regulating response to simulated microgravity stress. Among the intestinal lncRNAs,  linc-2 ,  linc-46 ,  linc-61 , and  linc-78  were increased by simulated microgravity treatment, and  linc-13 ,  linc-14 ,  linc-50 , and  linc-125  were decreased by simulated microgravity treatment. Among these 8 intestinal lncRNAs, RNAi knockdown of  linc-2  or  linc-61  induced a susceptibility to toxicity of simulated microgravity, whereas RNAi knockdown of  linc-13 ,  linc-14 , or  linc-50  induced a resistance to toxicity of simulated microgravity. In simulated microgravity treated nematodes,  linc-50  potentially binds to three transcriptional factors (DAF-16, SKN-1, and HLH-30). RNAi knockdown of  daf-16 ,  skn-1 , or  hlh-30  could suppress resistance of  linc-50(RNAi)  nematodes to the toxicity of simulated microgravity. Therefore, our results provide an important basis for intestinal lncRNAs, such as the  linc-50 , in regulating the response to simulated microgravity in nematodes.

Intestinal long non-coding RNAs in response to simulated microgravity stress in Caenorhabditis elegans