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Deep brain stimulation (DBS) has become an effective therapeutic solution for Parkinson’s disease (PD). Adaptive closed-loop DBS can be used to minimize stimulation-induced side effects by automatically determining the stimulation parameters based on the PD dynamics. In this paper, by modeling the interaction between the neurons in populations of the thalamic, the network-level modulation of thalamic is represented in a standard canonical form as a multi-input multi-output (MIMO) nonlinear first-order system with uncertainty and external disturbances. A class of fast and robust MIMO adaptive fuzzy terminal sliding mode control (AFTSMC) has been presented for control of membrane potential of thalamic neuron populations through continuous adaptive DBS current applied to the thalamus. A fuzzy logic system (FLS) is used to estimate the unknown nonlinear dynamics of the model, and the weights of FLS are adjusted online to guarantee the convergence of FLS parameters to optimal values. The simulation results show that the proposed AFTSMC not only significantly produces lower tracking errors in comparison with the classical adaptive fuzzy sliding mode control (AFSMC), but also makes more robust and reliable outputs. The results suggest that the proposed AFTSMC provides a more robust and smooth control input which is highly desirable for hardware design and implementation.

Robust multi-input multi-output adaptive fuzzy terminal sliding mode control of deep brain stimulation in Parkinson’s disease: a simulation study