English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Despite the existing antibiotics, antimicrobial resistance is a major challenge. Consequently, the development of new drugs remains in great demand. Quinones is part of a broad group of molecules that present antibacterial activity besides other biological properties. The main purpose of this study was to evaluate the antibiofilm activities of synthetic  N , O -acetals derived from 2-amino-1,4-naphthoquinone [ 7a : 2-(methoxymethyl)-amino-1,4-naphthoquinone;  7b : 2-(ethoxymethyl)-amino-1,4-naphthoquinone; and  7c : 2-(propynyloxymethyl)-amino-1,4-naphthoquinone] against methicillin-resistant  Staphylococcus aureus  (MRSA). The derivatives  7b  and  7c , specially  7b , caused strong impact on biofilm accumulation. This inhibition was linked to decreased expression of the genes  fnbA ,  spa ,  hla  and  psmα3 . More importantly, this downregulation was paralleled by the modulation of global virulence regulators. The substitution of 2-ethoxymethyl ( 7b ) in comparison with 2-propynyloxymethyl ( 7c ) enhanced  sarA - agr  inhibition, decreased  fnbA  transcripts (positively regulated by  sarA ) and strongly impaired biofilm accumulation. Indeed,  7b  triggered intensive autolysis and was able to eliminate vancomycin-persistent cells. Consequently,  7b  is a promising molecule displaying not only antimicrobial effects, but also antibiofilm and antipersistence activities. Therefore,  7b  is a good candidate for further studies involving the development of novel and more rational antimicrobials able to act in chronic and recalcitrant infections, associated with biofilm formation.

scientific reports

Antibiofilm effects of N,O-acetals derived from 2-amino-1,4-naphthoquinone are associated with downregulation of important global virulence regulators in methicillin-resistant Staphylococcus aureus