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There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B 12  as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B 12 , and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group ( P  for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women ( P  for trend = 0.099 and 0.703, respectively). Plasma vitamin B 12  was positively associated with hypertension only in women ( P  for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B 12 .

Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study