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Arboviral infections such as dengue, Zika and chikungunya are fast spreading diseases that pose significant health problems globally. In order to control these infections, an intracellular bacterium called  Wolbachia  has been introduced into wild-type mosquito populations in the hopes of replacing the vector transmitting agent,  Aedes aegypti  with one that is incapable of transmission. In this study, we developed a  Wolbachia  transmission model for the novel  w Au strain which possesses several favourable traits (e.g., enhanced viral blockage and maintenance at higher temperature) but not cyctoplasmic incompatibility (CI)—when a  Wolbachia -infected male mosquito mates with an uninfected female mosquito, producing no viable offspring. This model describes the competitive dynamics between  w Au- Wolbachia -infected and uninfected mosquitoes and the role of imperfect maternal transmission. By analysing the system via computing the basic reproduction number(s) and stability properties, the potential of the  w Au strain as a viable strategy to control arboviral infections is established. The results of this work show that enhanced maintenance of  Wolbachia  infection at higher temperatures can overcome the lack of CI induction to support  w Au- Wolbachia  infected mosquito invasion. This study will support future arboviral control programs, that rely on the introduction of new  Wolbachia  variants.

Modeling the potential of wAu-Wolbachia strain invasion in mosquitoes to control Aedes-borne arboviral infections