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This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prognostic markers. Mutations of  HRAS ,  FGFR3 ,  PIK3CA  and  TERT  were found in 2.9%, 27.2%, 14.9% and 76.7% of tumor samples, respectively. Concerning NMIBC, on multivariate analysis,  RXRA  and  FGFR3  levels were associated with recurrence-free survival (RFS) ( p  = 0.0022 and  p  = 0.0069) and  RXRA  level was associated with progression to muscle-invasive disease ( p  = 0.0068). We identified a 3-gene molecular signature associated with NMIBC prognosis.  FGFR3  overexpression was associated with reduced response to Bacillus Calmette–Guerin treatment ( p  = 0.037). As regards MIBC, on multivariate analysis,  ERCC2  overexpression was associated with RFS ( p  = 0.0011) and  E2F3  and  EGFR  overexpression were associated with overall survival ( p  = 0.014 and  p  = 0.035). RT-PCR findings were confirmed by IHC for FGFR3. Genomic alterations in MIBC revealed in TCGA data also concern NMIBC and seem to be associated with prognosis in terms of recurrence and progression. Correcting these alterations by targeted therapies seems a promising pharmacological approach.

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Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer