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Sarcopenia is an independent predictor of mortality in patients with liver cirrhosis. However, evidence has emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we investigated whether irisin was associated with sarcopenia in patients with liver cirrhosis. This was an observational cross-sectional study of data collected from 187 cirrhotic patients. Sarcopenia was defined by computed tomography (CT) scans using specific cutoffs of the 3rd lumbar vertebra skeletal muscle index (L 3  SMI). Morning irisin levels were obtained in all patients. Of the 187 patients, sarcopenia was noted in 73 (39%). Irisin concentrations were lower in sarcopenic patients (32.40 pg/ml [interquartile range (IQR): 18.70, 121.26],  p  < 0.001) than in nonsarcopenic patients. There was a weak correlation between L 3  SMI and irisin levels ( r  = 0.516,  p  < 0.001). Multivariable regression analysis including L 3  SMI, body mass index (BMI), very-low-density lipoprotein (VLDL)-cholesterol, aspartate aminotransferase (AST), adiponectin, and irisin levels showed that L 3  SMI (odds ratio [ OR ] = 0.915,  p  = 0.023), adiponectin levels ( OR  = 1.074,  p  = 0.014), irisin levels ( OR  = 0.993,  p  < 0.001) and BMI ( OR  = 0.456,  p  = 0.004) were independently associated with sarcopenia. Irisin levels are associated with sarcopenia in patients with liver cirrhosis. This paper addresses a gap in the literature and facilitates the future transition into clinical treatment.

Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: a cross-sectional study