English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The use of faecal microbial markers as non-invasive biomarkers for colorectal cancer (CRC) has been suggested, but not fully elucidated. Here, we have evaluated the importance of  Parvimonas micra  as a potential non-invasive faecal biomarker in CRC and its relation to other microbial biomarkers. The levels of  P. micra ,  F. nucleatum  and  clbA  + bacteria were quantified using qPCR in faecal samples from a population-based cohort of patients undergoing colonoscopy due to symptoms from the large bowel. The study included 38 CRC patients, 128 patients with dysplasia and 63 controls. The results were validated in a second consecutive CRC cohort including faecal samples from 238 CRC patients and 94 controls. We found significantly higher levels of  P. micra  in faecal samples from CRC patients compared to controls. A test for  P. micra  could detect CRC with a specificity of 87.3% and a sensitivity of 60.5%. In addition, we found that combining  P. micra  with other microbial markers, could further enhance test sensitivity. Our findings support the potential use of  P. micra  as a non-invasive biomarker for CRC. Together with other microbial faecal markers,  P. micra  may identify patients with “high risk” microbial patterns, indicating increased risk and incidence of cancer.

Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer