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We used a randomized crossover experiment to estimate the effects of ozone (vs. clean air) exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours. Twenty-four hours after exposure, participants underwent bronchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K platform. We performed global and regional tests examining the ozone versus clean air effect on the DNA methylome and calculated Fisher-exact  p -values for a series of univariate tests. We found little evidence of an overall effect of ozone on the DNA methylome but some suggestive changes in  PLSCR1 ,  HCAR1 , and  LINC00336  DNA methylation after ozone exposure relative to clean air. We observed some participant-to-participant heterogeneity in ozone responses.

Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study