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MYO18B  has been proposed to contribute to the progression of hepatocellular carcinoma (HCC). However, the signals that govern  MYO18B  transcription are not known. Here we show that, a network of C19MC miRNA-520G, IFN-γ, CEBPB and p53 transcriptional-defects promote  MYO18B  mRNA expression in HCCs. IFN-γ by itself suppresses  MYO18B  transcription, but promotes it when miRNA-520G is stably overexpressed. Similarly, CEBPB-liver-enriched activator protein (LAP) isoform overexpression suppresses  MYO18B  transcription but promotes transcription when the cells are treated with IFN-γ. Furthermore, miR-520G together with mutant-p53 promotes  MYO18B  transcription. Conversely, bFGF suppresses  MYO18B  mRNA irrespective of CEBPB, miR-520G overexpression or IFN-γ treatment. Finally high  MYO18B  expression reflects poor prognosis while high  MYL5  or  MYO1B  expression reflects better survival of HCC patients. Thus, we identified a network of positive and negative regulators of  MYO18B  mRNA expression which reflects the survival of HCC patients.

Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma