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Carbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g. ,  potentiometric, spectroscopic (ATR, UV, XRD powder, 1 H and 13 C NMR), electrochemical (cyclic voltammetry), and optical techniques, to receive the complete structural analysis, physicochemical (pKa, logP) and biological profile of a new carbazole derivative with acronym  3,6-PIRAMICAR . The interaction ability of the compound studied with potential cellular targets like  Calf Thymus  DNA ( CT -DNA), or  Bovine Serum Albumin  (BSA) were also taken into account. Experiments showed the existence of strong binding, but no DNA or BSA cleavage was observed .  The comparative analyzes of compounds anti- Candida  action clearly show pH-dependent antifungal activity of  3,6-PIRAMICAR , which was strongly stimulated in the acidic media. Surprisingly, the titled compound turn out to be much more effective (14 times by MIC50; 8 times by MIC;  c.a.  4 times by MFC) against  Candida krusei  than fluconazole at pH 4.

Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent