English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Fusarium  head blight (FHB) caused by  Fusarium graminearum  ( Fg ) is a devastating disease of crops, especially wheat and barley, resulting in significant yield loss and reduced grain quality.  Fg  infection leads to the production of mycotoxins, whose consumption is toxic to humans and livestock. The Arabidopsis  DMR6  gene encodes a putative 2-oxoglutarate Fe(II)-dependent oxygenase ( 2OGO ) and has been identified as a susceptibility factor to downy mildew. We generated site-specific mutations in Arabidopsis  At2OGO  by CRISPR/Cas9 gene editing. The resulting  At2OGO  knock-out (KO) mutants display enhanced resistance to  Fg  in a detached inflorescence infection assay. Expression profiling of defense genes revealed that impairment of  At2OGO  function resulted in the upregulation of defense genes that are regulated by salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) pathways. Complementation of the  At2OGO -KO lines with a barley (cv. Conlon) orthologue,  Hv2OGO , restored susceptibility to  Fg . This result indicates that the  Hv2OGO  gene is functionally equivalent to its Arabidopsis counterpart and, hence, may have a similar role in conditioning susceptibility to FHB in barley. These results provide a molecular basis for proposing  2OGO  as a plant immunity suppressor in Arabidopsis and potentially in barley plants and establish a rationale and strategy for enhancing FHB resistance in barley.

Validation of barley 2OGO gene as a functional orthologue of Arabidopsis DMR6 gene in Fusarium head blight susceptibility