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Neisseria gonorrhoeae , the causative agent of gonorrhea, is an exclusive human pathogen whose growing antibiotic resistance is causing worldwide concern. The increasing rise of antibiotic resistance expressed by gonococci highlights the need to find alternative approaches to current gonorrhea treatment such as vaccine development or novel therapeutics. The gonococcal OmpA protein was previously identified as a potential vaccine candidate due to its conservation and stable expression amongst strains of  Neisseria gonorrhoeae . However, factors that might modulate levels of OmpA and therefore potential vaccine efficacy are unknown. Earlier work indicated that  ompA  is part of the MisR/MisS regulon and suggested that it was a MisR-activated gene. Herein, we confirmed MisR/MisS regulation of  ompA  and report that the MisR response regulator can bind upstream of the  ompA  translational start codon. Further, we describe the contribution of a DNA sequence upstream of the  ompA  promoter that is critical for MisR activation of  ompA  transcription. Our results provide a framework for understanding the transcription of gonococcal  ompA  through a regulatory system known to be important for survival of gonococci during experimental infection.

Transcriptional control of the gonococcal ompA gene by the MisR/MisS two-component regulatory system