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Gap junction channels made of different connexins have distinct permeability to second messengers, which could affect many cell processes, including lens epithelial cell division. Here, we have compared the permeability of IP 3  and Ca 2+  through channels made from two connexins, Cx43 and Cx50, that are highly expressed in vertebrate lens epithelial cells. Solute transfer was measured while simultaneously monitoring junctional conductance via dual whole-cell/perforated patch clamp. HeLa cells expressing Cx43 or Cx50 were loaded with Fluo-8, and IP 3  or Ca 2+  were delivered via patch pipette to one cell of a pair, or to a monolayer while fluorescence intensity changes were recorded. Cx43 channels were permeable to IP 3  and Ca 2+ . Conversely, Cx50 channels were impermeable to IP 3 , while exhibiting high permeation of Ca 2+ . Reduced Cx50 permeability to IP 3  could play a role in regulating cell division and homeostasis in the lens.

Connexin43 and connexin50 channels exhibit different permeability to the second messenger inositol triphosphate