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Skin cancer risk information based on melanocortin-1 receptor ( MC1R ) variants could inform prevention and screening recommendations for Hispanics, but limited evidence exists on the impact of  MC1R  variants in Hispanic populations. We studied Hispanic subjects, predominately of Puerto Rican heritage, from Tampa, Florida, US, and Ponce, PR. Blood or saliva samples were collected by prospective recruitment or retrieved from biobanks for genotyping of  MC1R  variants and ancestry informative markers. Participant demographic and self-reported phenotypic information was collected via biobank records or questionnaires. We determined associations of  MC1R  genetic risk categories and phenotypic variables and genetic ancestry. Over half of participants carried  MC1R  variants known to increase risk of skin cancer, and there was diversity in the observed variants across sample populations. Associations between  MC1R  genetic risk groups and some pigmentation characteristics were identified. Among Puerto Ricans, the proportion of participants carrying  MC1R  variants imparting elevated skin cancer risk was consistent across quartiles of European, African, and Native American genetic ancestry. These findings demonstrate that  MC1R  variants are important for pigmentation characteristics in Hispanics and that carriage of high risk  MC1R  alleles occurs even among Hispanics with stronger African or Native American genetic ancestry.

MC1R variants and associations with pigmentation characteristics and genetic ancestry in a Hispanic, predominately Puerto Rican, population