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SOX3 is a transcription factor expressed within the developing and adult nervous system where it mostly functions to help maintain neural precursors.  Sox3  is also expressed in other locations, notably within the spermatogonial stem/progenitor cell population in postnatal testis. Independent studies have shown that  Sox3  null mice exhibit a spermatogenic block as young adults, the mechanism of which remains poorly understood. Using a panel of spermatogonial cell marker genes, we demonstrate that  Sox3  is expressed within the committed progenitor fraction of the undifferentiated spermatogonial pool. Additionally, we use a  Sox3  null mouse model to define a potential role for this factor in progenitor cell function. We demonstrate that  Sox3  expression is required for transition of undifferentiated cells from a GFRα1+ self-renewing state to the NGN3 + transit-amplifying compartment. Critically, using chromatin immunoprecipitation, we demonstrate that SOX3 binds to a highly conserved region in the  Ngn3  promoter region  in vivo , indicating that  Ngn3  is a direct target of SOX3. Together these studies indicate that SOX3 functions as a pro-commitment factor in spermatogonial stem/progenitor cells.

SOX3 promotes generation of committed spermatogonia in postnatal mouse testes