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A study was conducted to determine the cytosolic  in vitro  hepatic enzymatic kinetic parameters V  m  a  x  , K  M  , and intrinsic clearance (CL  i  n  t  ) for aflatoxin B 1  (AFB 1 ) reductase [aflatoxicol (AFL) production] and AFL dehydrogenase (AFB 1  production) in four commercial poultry species (chicken, quail, turkey and duck). Large differences were found in AFB 1  reductase activity, being the chicken the most efficient producer of AFL (highest CL  i  n  t   value). Oxidation of AFL to AFB 1  showed only slight differences among the different poultry species. On average all species produced AFB 1  from AFL at a similar rate, except for the turkey which produced AFB 1  from AFL at a significantly lower rate than chickens and quail, but not ducks. Although the turkey and duck showed differences in AFL oxidation V  m  a  x   and K  M   parameters, their CL  i  n  t   values did not differ significantly. The ratio AFB 1  reductase/AFL dehydrogenase enzyme activity was inversely related to the known  in vivo  sensitivity to AFB 1  being highest for the chicken, lowest for the duck and intermediate for turkeys and quail. Since there is no evidence that AFL is a toxic metabolite of AFB 1 , these results suggest that AFL production is a detoxication reaction in poultry. Conversion of AFB 1  to AFL prevents the formation of the AFB 1 -8,9- exo -epoxide which, upon conversion to AFB 1 -dihydrodiol, is considered to be the metabolite responsible for the acute toxic effects of AFB 1 .

In vitro hepatic aflatoxicol production is related to a higher resistance to aflatoxin B1 in poultry