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The possibility to use  β  −  decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on  ex-vivo  samples of Meningioma and intestinal Neuroendocrine Tumor (NET) have been published. This paper reports a study of the uptake of  68 Ga-DOTATOC in pancreatic NETs (pNETs) in order to assess the feasibility of a new RGS approach using  90 Y-DOTATOC. Tumor and healthy pancreas uptakes were estimated from  68 Ga-DOTATOC PET/CT scans of 30 patients with pNETs. From the obtained SUVs (Standardised Uptake Value) and TNRs (Tumor Non tumor Ratio), an analysis algorithm relying on a Monte Carlo simulation of the detector has been applied to evaluate the performances of the proposed technique. Almost all considered patients resulted to be compatible with the application of  β  − -RGS assuming to administer 1.5 MBq/kg of activity of  90 Y-DOTATOC 24 h before surgery, and a sampling time of few seconds. In just 2 cases the technique would have required a mildly increased amount of activity or of sampling time. Despite a high physiological uptake of  68 Ga-DOTATOC in the healthy pancreas, the proposed RGS technique promises to be effective. This approach allows RGS to find application also in pancreatic diseases, where traditional techniques are not viable.

Radioguided surgery with β− radiation in pancreatic Neuroendocrine Tumors: a feasibility study