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The antibiotic 2,4-diacetylphoroglucinol (2,4-DAPG), produced by the Gram-negative rod-shaped bacterium  Pseudomonas fluorescens  2P24, is active against various soil-borne bacterial and fungal pathogens that cause plant diseases. Biosynthesis of 2,4-DAPG is controlled by regulating expression of the  phlACBD  operon at the post-transcriptional level. The  phlG  gene is located between the  phlF  and  phlH  genes, upstream of the  phlACBD  biosynthetic operon. Herein, we cloned the  phlG  gene, generated a  phlG  deletion mutant, and investigated its regulatory role in 2,4-DAPG biosynthesis. The results showed that deletion of  phlG  had no effect on the biosynthesis of 2,4-DAPG, but it affected conversion of 2,4-DAPG to its precursor monoacetylphloroglucinol (MAPG). The global regulatory factor encoded by  gacS  positively regulated expression of  phlG , while  rsmE  negatively regulated its expression. Deleting  phlG  did not alter the ability of the bacterium to colonise plants or promote plant growth. These results suggest that  phlG  collaborates with other factors to regulate production of the antibiotic 2,4-DAPG in  P. fluorescens  2P24.

PhlG mediates the conversion of DAPG to MAPG in Pseudomonas fluorescens 2P24