English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Involvement of long non-coding RNAs (lncRNAs) in the regulation of gene expression in  cis  has been well studied in eukaryotes but relatively little is known whether and how lncRNAs affect gene expression in  tans . In  Arabidopsis thaliana ,  COLDAIR , a previously reported lncRNA, is produced from the first intron of  FLOWERING LOCUS C  ( FLC ), which encodes a repressor of flowering time. Our results indicated that the exogenously overexpressed  COLDAIR  enhances the expression of  FLC  in  trans , resulting in a late-flowering phenotype. In  35S-COLDAIR  lines, the enhanced expression of  FLC  is correlated with the down-regulation of the repressive histone mark H3K27me3 and with the up-regulation of the active histone mark H3K4me3 at the  FLC  chromatin. Furthermore, we demonstrated that overexpression of intronic lncRNAs from several other H3K27me3-enriched MADS-box genes also activates the expression of their host genes. This study suggests that the involvement of overexpressed intronic lncRNAs in gene activation may be conserved in H3K27me3-enriched genes in eukaryotes.

Exogenously overexpressed intronic long noncoding RNAs activate host gene expression by affecting histone modification in Arabidopsis