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Salmonella  typhimurium is a pathogenic gram-negative bacterium, which is found primarily in the intestinal lumen. It often causes diarrhea in infants and young children and leads to food poisoning. Drug resistance of  Salmonella  typhimurium presented serious complications in clinical patients. In this study, we investigated the antibiotic susceptibility of  Salmonella  typhimurium standard strain L forms to the third and forth generation cephalosporins, in order to control and eliminate  Salmonella  typhimurium L forms in infection treatment.  Salmonella  typhimurium L forms were induced by β-lactam antibiotic cefazolin in the culture medium of bacterial L forms. The antibiotic susceptibility of  Salmonella  typhimurium L forms was analyzed by K-B drug susceptibility testing. The change trend of drug susceptibility and resistance of  Salmonella  typhimurium L forms was obtained in accordance with USA clinical and laboratory standards institute (CLSI) evaluation data and statistical analysis. Drug resistance of  Salmonella  typhimurium L forms showed little increasing trend compared with their parent bacteria. The L form inhibition zone was smaller than in the parent bacteria. However, the drug susceptibility of L forms of  Salmonella  typhimurium to the third and forth generation cephalosporins remained sensitive.The antibiotic susceptibility of  Salmonella  typhimurium L forms to the third and forth generation cephalosporins remains sensitive, and the combined use of multi-antibiotics is a convenient and effective method to reduce  Salmonella  typhimurium L forms occurrence.

Study on antibiotic susceptibility of Salmonella typhimurium L forms to the third and forth generation cephalosporins