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Waddlia chondrophila  is an intracellular bacterium phylogenetically related to the well-studied human and animal pathogens of the  Chlamydiaceae  family. In the last decade,  W. chondrophila  was convincingly demonstrated to be associated with adverse pregnancy outcomes in humans and abortions in animals. All members of the phylum  Chlamydiae  possess a Type Three Secretion System that they use for delivering virulence proteins into the host cell cytosol to modulate their environment and create optimal conditions to complete their life cycle. To identify  W. chondrophila  virulence proteins, we used an original screening approach that combines a cosmid library with an assay monitoring resistance to predation by phagocytic amoebae. This technique combined with bioinformatic data allowed the identification of 28 candidate virulence proteins, including Wimp1, the first identified inclusion membrane protein of  W. chondrophila .

A predation assay using amoebae to screen for virulence factors unearthed the first W. chondrophila inclusion membrane protein