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Insulin family peptides are known to be key regulators of growth and metabolism in insects and vertebrates. Insects have two types of insulin family peptides: insulin-like peptides and insulin-like growth factor (IGF)-like peptides (IGFLPs). We recently demonstrated that an IGFLP in the silkmoth,  Bombyx mori  (BIGFLP) promotes the growth of the genital imaginal disc  ex vivo . However, the role of BIGFLP in the regulation of insect growth remains unclear because no  in vivo  study has been performed. Therefore, we analysed the functions of BIGFLP  in vivo  by constructing  BIGFLP  knock-out (KO)  B .  mori  using the clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated protein 9 (CRISPR-Cas9) system. The KO moths exhibited decreased body weights and size of the appendages compared wild-type (wt) moths. Interestingly, KO females also had drastically lower ovary weights and number of eggs than wt females. However, mutant ovaries that were transplanted into wt host pupae reached a similar weight to wt ovaries that were transplanted into the wt hosts, suggesting that IGFLP in the haemolymph promotes ovarian development. These findings show that BIGFLP regulates the growth and development of adult organs, particularly the ovaries, in  B .  mori .

An insulin-like growth factor-like peptide promotes ovarian development in the silkmoth Bombyx mori