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Although the clinical importance of extragraft bone formation (ExGBF) and bridging (ExGBB) has been reported, few studies have investigated the biomechanical influences of ExGBF on the motion segment. In this study, ExGBF was simulated at the C5-C6 motion segment after anterior cervical discectomy and fusion using a developed finite element model and a sequential bone-remodelling algorithm in flexion and extension. The computer simulation results showed that extragraft bone was primarily formed in the extension motion and grew to form ExGBB. A stepwise decrease in the intersegmental rotation angle, maximum von Mises stress and strain energy density on the trabecular bone with ExGBF were predicted in extension. When ExGBB was formed in the trabecular bone region, the intersegmental rotation angle slightly decreased with additional bone formation. However, the stress and strain energy density on the trabecular bone region decreased until ExGBB reached the peripheral cortical margin. The results offer a rationale supporting the hypothesis that mechanical stimuli influence ExGBF. ExGBF was helpful in increasing the stability of the motion segment and decreasing the fracture risk of trabecular bones, even in cases in which ExGBB was not formed. ExGBB can be classified as either soft or hard bridging based on a biomechanical point of view.

scientific reports

Biomechanical investigation of extragraft bone formation influences on the operated motion segment after anterior cervical spinal discectomy and fusion