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Willaertia magna  c2c maky is a thermophilic amoeba closely related to the genus  Naegleria . This free-living amoeba has the ability to eliminate  Legionella pneumophila , which is an amoeba-resisting bacterium living in an aquatic environment. To prevent the proliferation of  L. pneumophila  in cooling towers, the use of  W. magna  as natural biocide has been proposed. To provide a better understanding of the  W. magna  genome, whole-genome sequencing was performed through the study of virulence factors and lateral gene transfers. This amoeba harbors a genome of 36.5 megabases with 18,519 predicted genes. BLASTp analyses reported protein homology between 136  W. magna  sequences and amoeba-resistant microorganisms. Horizontal gene transfers were observed based on the basis of the phylogenetic reconstruction hypothesis. We detected 15 homologs of  N. fowleri  genes related to virulence, although these latter were also found in the genome of  N. gruberi , which is a non-pathogenic amoeba. Furthermore, the cytotoxicity test performed on human cells supports the hypothesis that the strain c2c maky is a non-pathogenic amoeba. This work explores the genomic repertory for the first draft genome of genus  Willaertia  and provides genomic data for further comparative studies on virulence of related pathogenic amoeba,  N. fowleri .

Investigation of potential pathogenicity of Willaertia magna by investigating the transfer of bacteria pathogenicity genes into its genome