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Vitamin C (VC) and vitamin D (VD) have been widely used as the dietary supplements and in treatment of diseases both independently and in combination. Whether there is a connection between their pathways is critical for their therapeutic applications. Using whole-genome expression profiles, we performed multiple measures of associations, networks, eQTL mappings and expressions of key genes of interest in VC and VD functions. Several key genes in their pathways were found to be associated.  Gc  and  Rgn  play important roles connecting VC and VD pathways in mice. The r values of expression levels between  Gc  and  Rgn  in mouse spleen, liver, lung, and kidney are 0.937, 0.558, 0.901, and 0.617, respectively. The expression QTLs of  Gc  and  Rgn  are mapped onto the same locations, i.e., 68–76 MB in chromosome 7 and 26–36 MB in chromosome 9. In humans, there are positive correlations between  CYP27B1  and  SLC23A1  expression levels in kidney (r = 0.733) and spleen (r = 0.424).  SLC23A2  and  RXRA  are minimally associated in both mouse and human. These data indicate that pathways of VC and VD are not independent but affect each other, and this effect is different between mice and humans during VC and VD synthesis and transportation.

Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared