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The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and cerebrovascular impairments  in vitro . Recent technological advancements in BBB modeling using induced pluripotent stem cells (iPSCs) allowed to overcome some of these obstacles, nonetheless the pertinence for their use in drug permeation study remains to be established. This mandatory information requires a cross comparison of  in vitro  and  in vivo  pharmacokinetic data in the same species to avoid failure in late clinical drug development. Here, we measured the BBB permeabilities of 8 clinical positron emission tomography (PET) radioligands with known pharmacokinetic parameters in human brain  in vivo  with a newly developed  in vitro  iPSC-based human BBB (iPSC-hBBB) model. Our findings showed a good correlation between  in vitro  and  in vivo  drug brain permeability (R 2  = 0.83;  P  = 0.008) which contrasted with the limited correlation between  in vitro  apparent permeability for a set of 18 CNS/non-CNS compounds using the  in vitro  iPSCs-hBBB model and drug physicochemical properties. Our data suggest that the iPSC-hBBB model can be integrated in a flow scheme of CNS drug screening and potentially used to study species differences in BBB permeation.

Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model