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Gram-negative bacteria belonging to the genus  Klebsiella  are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as  Escherichia ,  Pseudomonas  and  Salmonella . This study is the first report describing pore-forming and peptidoglycan-degrading bacteriocins klebicins from  Klebsiella . We have identified, cloned, expressed in plants and characterized nine pore-forming and peptidoglycan-degrading bacteriocins from different  Klebsiella  species. We demonstrate that klebicins can be used for broad and efficient control of 101 of the 107 clinical isolates representing five  Klebsiella  species, including multi-drug resistant pathovars and pathovars resistant to carbapenem antibiotics.

Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins