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Akkermansia muciniphila  utilises colonic mucin as its substrate. Abundance is reduced in ulcerative colitis (UC), as is the relative proportion of sulphated mucin in the mucus gel layer (MGL). It is unknown if these phenomena are related, however reduced sulphated mucins could contribute to reduced abundance, owing to a lack of substrate. The aim of this study was to quantify  A. muciniphila  within the MGL and to relate these findings with markers of inflammation and the relative proportion of sulphomucin present. Colonic biopsies and mucus brushings were obtained from 20 patients with active UC (AC), 14 with quiescent UC (QUC) and 20 healthy controls (HC).  A. muciniphila  abundance was determined by RT-PCR. High iron diamine alcian-blue staining was performed for histological analysis. Patients with AC had reduced abundance of  A. muciniphila  compared to HC and QUC. A positive association was found between  A. muciniphila  abundance and higher percentage of sulphated mucin (ρ 0.546, p = 0.000). Lower abundances of  A. muciniphila  correlated with higher inflammatory scores (ρ = 0.294 (p = 0.001)). This study confirms an inverse relationship between  A. muciniphila  and inflammation and a positive association between  A. muciniphila  abundance and percentage of sulfated mucin in the MGL.

The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis