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Spermatogenesis is a differentiation process that requires dramatic changes to DNA architecture, a process governed in part by Transition Nuclear Proteins 1 and 2 (TNP1 and TNP2). Translation of  Tnp1  and  Tnp 2 mRNAs is temporally disengaged from their transcription. We hypothesized that RNA regulatory proteins associate specifically with  Tnp  mRNAs to control the delayed timing of their translation. To identify potential regulatory proteins, we isolated endogenous mRNA/protein complexes from testis extract and identified by mass spectrometry proteins that associated with one or both  Tnp  transcripts. Five proteins showed strong association with  Tnp  transcripts but had low signal when  Actin  mRNA was isolated. We visualized the expression patterns in testis sections of the five proteins and found that each of the proteins was detected in germ cells at the appropriate stages to regulate  Tnp  RNA expression.

Mass spectrometric identification of candidate RNA-binding proteins associated with Transition Nuclear Protein mRNA in the mouse testis