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Human milk oligosaccharides (HMOs) shape gut microbiota during infancy by acting as fermentable energy source. Using a semi-continuous colon simulator, effect of an HMO, 2′-fucosyllactose (2′-FL), on composition of the infant microbiota and microbial metabolites was evaluated in comparison to galacto-oligosaccharide (GOS) and lactose and control without additional carbon source. Data was analysed according to faecal sample donor feeding type: breast-fed (BF) or formula-fed (FF), and to rate of 2′-FL fermentation: fast or slow. Variation was found between the simulations in the ability to utilise 2′-FL. The predominant phyla regulated by 2′-FL, GOS and lactose were significant increase in Firmicutes, numerical in Actinobacteria, and numerical decrease in Proteobacteria compared to control. Verrucomicrobia increased in FF accounted for  Akkermansia , whereas in fast-fermenting simulations Actinobacteria increased with trend for higher  Bifidobacterium , and Proteobacteria decrease accounted for  Enterobacteriaceae . Short-chain fatty acids and lactic acid with 2′-FL were produced in intermediate levels being between ones generated by the control and GOS or lactose. In 2′-FL fast-fermenting group, acetic acid specifically increased with 2′-FL, whereas lactose and GOS also increased lactic acid. The results highlight specificity of 2′-FL as energy source for only certain microbes over GOS and lactose in the simulated gut model.

The effect of 2′-fucosyllactose on simulated infant gut microbiome and metabolites; a pilot study in comparison to GOS and lactose