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The therapeutic effects of  B .  coagulans  Unique IS2 have been well established in children with irritable bowel syndrome (IBS), but its efficacy in adults remain under reported. Thus, in this study the efficacy of  B .  coagulans  Unique IS2 in the management of IBS symptoms in adults was investigated. Patients ( n  = 153) fulfilling Rome III criteria were provided placebo capsules for a 2 weeks run-in period. Only patients satisfying compliance criteria ( n  =  136 ) were randomized (double blind) to receive either  B .  coagulans  Unique IS2 (2 billion CFU) or placebo capsules daily for 8 weeks. Reduction of abdominal discomfort/pain intensity and increase in complete spontaneous bowel movements were analyzed as primary end points. Other clinical symptoms of IBS and serum cytokines were also evaluated.  B .  coagulans  Unique IS2 showed significant improvement in primary and secondary endpoints, as compared to placebo. Haematology of both the arms remained normal. No significant changes in pro- (IL-6, IL-12, TNF-α, INF- γ) and anti-inflammatory cytokine (IL-10) levels were detected at the end of  B .  coagulans  treatment (8 weeks) as compared to placebo.  B .  coagulans  was well tolerated with no severe adverse events to report. Overall, the results demonstrate that  B .  coagulans  Unique IS2 is efficacious in the management of IBS symptoms in adults (18–60 years).

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Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults