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The Gram-positive bacterium  Listeria monocytogenes  occurs ubiquitously in the environment and infects humans upon ingestion. It encodes four PadR-like repressors, out of which LftR has been characterized previously and was shown to control gene expression in response to the antibiotic aurantimycin produced by other environmental bacteria. To better understand the PadR regulons of  L .  monocytogenes , we performed RNA-sequencing with mutants of the other three repressors LadR, LstR and Lmo0599. We show that LadR is primarily responsible for the regulation of the  mdrL  gene, encoding an efflux pump, while LstR and Lmo0599 mainly regulate their own operons. The  lstR  operon contains the  lmo0421  gene, encoding a homolog of the RodA/FtsW protein family. However, this protein does not possess such functionality, as we demonstrate here. The  lmo0599  operon contains two additional genes coding for the hypothetical trans-membrane proteins  lmo0600  and  lmo0601 . A striking phenotype of the  lmo0599  mutant is its impaired growth at refrigeration temperature. In light of these and other results we suggest that Lmo0599 should be renamed and propose LltR ( l isterial  l ow  t emperature  r egulator) as its new designation. Based on the nature of the PadR target genes we assume that these repressors collectively respond to compounds acting on the cellular envelope.

PadR-type repressors controlling production of a non-canonical FtsW/RodA homologue and other trans-membrane proteins