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The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this study, we compared staphylococci isolates recovered from high frequency touched surfaces from public areas in the community and hospitals in East and West London. 281 out of 600 (46.83%) staphylococci isolates recovered were multidrug resistant, of which 49 (8.17%) were  mecA  positive. There was significantly higher proportion of multidrug resistant staphylococci (P = 0.0002) in East London (56.7%) compared to West London (49.96%). The most common species identified as multidrug resistant were  S .  epidermidis ,  S .  haemolyticus  and  S .  hominis , whereas penicillin, fusidic acid and erythromycin were the most frequent antibiotics the isolates were resistant to. Whole genome sequenced of  mecA  positive isolates revealed that  S .  sciuri  isolates carried the  mecA1  gene, which has only 84.43% homology with  mecA . In addition, other frequently identified resistance genes included  blaZ ,  qacA/B  and  dfrC . We have also identified a diverse range of SCC mec  types, many of which were untypable due to carrying a novel combination of  ccr  genes or multiple  ccr  complexes.

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Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London