English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Cryptochrome (CRY) plays an important role in the input of circadian clocks in various species, but gene copies in each species are evolutionarily divergent. Type I CRYs function as a photoreceptor molecule in the central clock, whereas type II CRYs directly regulate the transcriptional activity of clock proteins. Functions of other types of animal CRYs in the molecular clock remain unknown. The water flea  Daphnia magna  contains four  Cry  genes. However, it is still difficult to analyse these four genes. In this study, we took advantage of powerful genetic resources available from  Drosophila  to investigate evolutionary and functional differentiation of CRY proteins between the two species. We report differences in subcellular localisation of each  D. magna  CRY protein when expressed in the  Drosophila  clock neuron. Circadian rhythm behavioural experiments revealed that  D. magna  CRYs are not functionally conserved in the  Drosophila  molecular clock. These findings provide a new perspective on the evolutionary conservation of CRY, as functions of the four  D. magna  CRY proteins have diverse subcellular localisation levels. Furthermore, molecular clocks of  D. magna  have been evolutionarily differentiated from those of  Drosophila . This study highlights the extensive functional diversity existing among species in their complement of  Cry  genes.

Analysing the evolutional and functional differentiation of four types of Daphnia magna cryptochrome in Drosophila circadian clock