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Campylobacter  infections sourced mainly to poultry products, are the most important bacterial foodborne zoonoses worldwide. No effective measures to control these infections in broiler production exist to date. Here, we used passive immunization with hyperimmune egg yolks to confer broad protection of broilers against  Campylobacter  infection. Two novel vaccines, a bacterin of thirteen  Campylobacter jejuni  ( C .  jejuni ) and  C .  coli  strains and a subunit vaccine of six immunodominant  Campylobacter  antigens, were used for the immunization of layers, resulting in high and prolonged levels of specific immunoglobulin Y (IgY) in the hens’ yolks. In the first  in vivo  trial, yolks (sham, bacterin or subunit vaccine derived) were administered prophylactically in the broiler feed. Both the bacterin- and subunit vaccine-induced IgY significantly reduced the number of  Campylobacter- colonized broilers. In the second  in vivo  trial, the yolks were administered therapeutically during three days before euthanasia. The bacterin IgY resulted in a significant decrease in  C .  jejuni  counts per infected bird. The hyperimmune yolks showed strong reactivity to a broad representation of  C .  jejuni  and  C .  coli  clonal complexes. These results indicate that passive immunization with hyperimmune yolks, especially bacterin derived, offers possibilities to control  Campylobacter  colonization in poultry.

Reducing Campylobacter jejuni colonization in broiler chickens by in-feed supplementation with hyperimmune egg yolk antibodies