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The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data were collected both from patients enrolled for this study, and from public datasets. In FL the ICT-GEP indicated the overexpression of both the K +  channel encoding gene  KCNN4 , and  SLC2A1 , which encodes the Glut1 glucose transporter.  SLC2A1  turned out to represent the hub of a functional network, connecting channels and transporters in FL. Relapsed FL patients were characterised by 38 differentially expressed ICT genes, among which  ATP9A ,  SLC2A1  and  KCNN4  were under-expressed, indicating a down-regulation of both excitability and glycolysis. A completely different profile of K +  channel encoding genes emerged in DLBCL accompanied by the over-expression of the fatty acid transporter-encoding gene  SLC27A1  as well as of the metabolism regulator  NCoR1 . This indicates a change in excitability and a shift towards an oxidative metabolism in DLBCL. Overall, the ICT-GEP may contribute to identifying novel lymphoma biomarkers related to excitability and metabolic pathways, with particular relevance for drug resistant, relapsed FL.

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The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma